The Effectiveness of Tepid Sponge Bath with 32oc and 37oc to Decrease Body Temperature at Toddler with Fever

Introduction: Tepid sponge bath is a therapeutic bath by washing all around of the body with warm water to decrease body temperature. Warm water that used were 32oC (nail warm) and 37oC (warm). The aimed of this study was to compare the effectivity of tepid sponge bath with 32oC and 37oC warm water on decreasing body temperature at toddler with fever. Method: A quasy experimental pre post test design was used in this study. The population was toddler who had body temperature ≥38oC which treated in anggrek pediatric room dr. Iskak public hospital Tulungagung. There were 26 respondents recruited by using purposive sampling technique and divided into two group, each of 13 respondents received tepid sponge bath with 32oC and others received tepid sponge bath with 37oC warm water. The independent variable was tepid sponge bath and dependent variable was body temperature. Data were collected by using digital termometere and noted in respondent observation, then analyzed by using Paired t-Test and Mann Withney U-Test. Result: The result showed that there was an effectivity on decreasing body temperature by giving tepid sponge bath with 32oC and 37oC warm water with significance level p=0.000 and there was a difference decreasing body temperature among both of them with significance level p=0.016. Discussion: It can be concluded that tepid sponge bath with 37oC warm water was more effective than tepid sponge bath with 32oC warm water. Further studies should be observed the effectivity of tepid sponge bath with more specific age, fever character and more time and respondent

Expressão não equilibrada do receptor de hidrocarboneto arílico nos linfócitos T CCR6+ CD4+ e CD4+ CD25+ do sangue periférico na artrite reumatoide

ResumoObjetivoAnalisar o papel do receptor de hidrocarboneto arílico (AhR) nos linfócitos T CCR6+ CD4+ e CD4+ CD25+ no sangue periférico de pacientes com artrite reumatoide (AR).MétodosFoi aplicada citometria de fluxo para determinar a proporção de células AhR positivas em linfócitos CCR6+ CD4+ e CD4+ CD25+ do sangue periférico e células mononucleares periféricas de cada indivíduo. Os níveis de expressão relativa de ácido ribonucleico mensageiro (do inglês ribonucleic acid, RNAm,) de AhR e RNAm de enzima de primeiro estágio essencial para o AhR (CYP1A1) foram testados por reação em cadeia de polimerase (do inglês polymerase chain reaction, PCR,) em tempo real.ResultadosA percentagem de células AhR positivas nas células mononucleares do sangue periférico foi maior no grupo com AR do que nos indivíduos saudáveis [(35,23±10,71)% vs. (18,83±7,32)%, (p<0,01)]. Os níveis de expressão de AhR e CYP1A1 estavam aumentados em pacientes com AR quando comparados com os controles [(3,71±1,63) vs. (2,00±1,27), p=0,002; (2,62±2,08) vs. (0,62±0,29), p<0,01, respectivamente]. Em pacientes com AR, a percentagem de células AhR positivas nos linfócitos T CD4+ CD25+ foi significativamente inferior à dos controles [17,90 (6,10±80,10)]% vs. (52,49±19,18)%, p < 0,01]; em controles saudáveis, a percentagem de células AhR positivas nos linfócitos T CD4+ CD25+ foi significativamente mais elevada do que nos linfócitos T CCR6+ CD4+ e também foi significativamente maior do que nas células mononucleares do sangue periférico (do inglês peripheral blood mononuclear cells, PBMC,) [(52,49±19,18)% vs. (23,18±5,62)% vs. (18,06±7,80)%, X 2=24,03, p < 0,01]; em pacientes com AR, a percentagem de células AHR positivas nos linfócitos T CCR6+ CD4+ era significativamente maior em comparação com os linfócitos T CD4+ CD25+ e PBMC (46,02±14,68)% vs. [17,90 (6,10±80.10)]% vs. (34,22±10,33)%, X 2=38,29, p<0,01]; no entanto, não foi encontrada correlação estatisticamente significativa entre os dados clínicos e células AhR positivas em linfócitos T CCR6+ CD4+ e CD4+ CD25+.ConclusãoO Ahr pode participar do progresso patológico da AR ao controlar a diferenciação de linfócitos Th17 e Treg no sangue periférico.AbstractObjectiveThe goal of this study was to analyze the role of aryl hydrocarbon receptor in peripheral blood CCR6+ CD4+ and CD4+ CD25+T cells of patients with rheumatoid arthritis.MethodsFlow cytometry was applied to determine the proportion of AhR positive cells in CCR6+ CD4+T, CD4+ CD25+T and peripheral blood peripheral mononuclear cells from each subject. AhR mRNA and CYP1A1 mRNA relative expression levels were tested by real‐time PCR.ResultsThe percentage of AhR positive cells in peripheral blood mononuclear cells was higher in RA group than that in healthy cases [(35.23±10.71) % vs. (18.83±7.32) %, (p<0.01)]. The expression levels of AhR and CYP1A1 were both increased in patients with RA while compared to controls [(3.71±1.63) vs. (2.00±1.27), p=0.002; (2.62±2.08) vs. (0.62±0.29), p<0.01, respectively]. In RA patients, the percentage of AhR positive cells in CD4+CD25+T cells was significantly lower than that from controls [17.90(6.10±80.10)]% vs. (52.49±19.18)%, p<0.01]; In healthy controls, the percentage of AhR positive cells in CD4+CD25+T cells was significantly higher than that in CCR6+CD4+T cells, and was also significantly higher than that in PBMCs [(52.49±19.18)% vs. (23.18±5.62)% vs. (18.06±7.80)%, X2=24.03, p<0.01]; in RA patients, the percentage of AhR positive cells in CCR6+CD4+T cells was significantly increased than that in CD4+CD25+T cells and PBMCs (46.02±14.68)% vs. [17.90 (6.10±80.10)] %vs. (34.22±10.33)%, X2=38.29, p<0.01]; Nevertheless, no statistically significant relationship was found between clinical data and AhR positive cells in CCR6+CD4+T and CD4+ CD25+T cells.ConclusionAhR may participate in the pathological progress of RA by controlling the differentiation of Th17 and Treg cells in peripheral blood

Vulnerability of welders to manganese exposure--a neuroimaging study

Increased manganese (Mn) exposure is known to cause cognitive, psychiatric and motor deficits. Mn exposure occurs in different occupational settings, where the airborne Mn level and the size of respirable particulates may vary considerably. Recently the importance of the role of the cerebral cortex in Mn toxicity has been highlighted, especially in Mn-induced neuropsychological effects. In this study we used magnetic resonance imaging (MRI) to evaluate brain Mn accumulation using T1 signal intensity indices and to examine changes in brain iron content using T2* contrast, as well as magnetic resonance spectroscopy (MRS) to measure exposure-induced metabolite changes non-invasively in cortical and deep brain regions in Mn-exposed welders, Mn-exposed smelter workers and control factory workers with no measurable exposure to Mn. MRS data as well as T1 signal intensity indices and T2* values were acquired from the frontal cortex, posterior cingulate cortex, hippocampus, and thalamus. Smelters were exposed to higher air Mn levels and had a longer duration of exposure, which was reflected in higher Mn levels in erythrocytes and urine than in welders. Nonetheless, welders had more significant metabolic differences compared to controls than did the smelter workers, especially in the frontal cortex. T1 hyperintensities in the globus pallidus were observed in both Mn-exposed groups, but only welders showed significantly higher thalamic and hippocampal T1 hyperintensities, as well as significantly reduced T2* values in the frontal cortex. Our results indicate that (1) the cerebral cortex, in particular the frontal cortex, is clearly involved in Mn neurotoxic effects and (2) in spite of the lower air Mn levels and shorter duration of exposure, welders exhibit more extensive neuroimaging changes compared to controls than smelters, including measurable deposition of Mn in more brain areas. These results indicate that the type of exposure (particulate sizes, dust versus fume) and route of exposure play an important role in the extent of Mn-induced toxic effects on the brain

Spatial beam self-cleaning in bi-tapered multimode fibers

We report the spatial beam self-cleaning in bi-tapered conventional multimode fibers (MMFs) with different tapered lengths. Through the introduction of the bi-tapered structure in MMFs, the input beam with poor beam quality from a high-power fiber laser can be converted to a centered, bell-shaped beam in a short length, due to the strengthened nonlinear modes coupling. It is found that the bi-tapered MMF with longer tapered length at the same waist diameter shows better beam self-cleaning effect and larger spectral broadening. The obtained results offer a new method to improve the beam quality of high-power laser at low cost. Besides, it may be interesting for manufacturing bi-tapered MMF-based devices to obtain the quasi-fundamental mode beam in spatiotemporal mode-locked fiber lasers

Coherent phonon dynamics in spatially separated graphene mechanical resonators

Vibrational modes in mechanical resonators provide a promising candidate to interface and manipulate classical and quantum information. The observation of coherent dynamics between distant mechanical resonators can be a key step towards scalable phonon-based applications. Here we report tunable coherent phonon dynamics with an architecture comprising three graphene mechanical resonators coupled in series, where all resonators can be manipulated by electrical signals on control gates. We demonstrate coherent Rabi oscillations between spatially separated resonators indirectly coupled via an intermediate resonator serving as a phonon cavity. The Rabi frequency fits well with the microwave burst power on the control gate. We also observe Ramsey interference, where the oscillation frequency corresponds to the indirect coupling strength between these resonators. Such coherent processes indicate that information encoded in vibrational modes can be transferred and stored between spatially separated resonators, which can open the venue of on-demand phonon-based information processing

The giant Upper Yangtze Pb-Zn province in SW China: Reviews, new advances and a new genetic model

In the western margin of the Yangtze Block, SW China, the Emeishan large igneous province (ELIP) is spatially associated with > 400 carbonate-hosted epigenetic Pb-Zn deposits. These deposits form the giant Upper Yangtze Pb-Zn metallogenic province with > 20 Mt base metals. In the southeastern part of this province, the important Pb-Zn deposits include those of the Yinchangpo, Yunluhe, Maozhachang, Tianqiao, Banbanqiao, Mangdong, Shaojiwan, Liangyan, Qingshan, Shanshulin, Nayongzhi and Guanziyao deposits. Sulfide ore bodies in these deposits are (i) hosted in late Ediacaran to middle Permian limestone, dolomitic limestone and dolostone; (ii) structurally controlled by reverse fault-anticline tectonic systems; and (iii) spatially associated with the ELIP flood basalts and mafic dikes, and early Permian, early Carboniferous and early Cambrian organic matter-rich black shales. C-O isotopic compositions suggest that dolostone and limestone, mantle-derived rocks of the ELIP, and sedimentary organic matters supplied C-O to the hydrothermal systems through water/rock (W/R) interaction. New and existing S isotopic compositions of sulfides imply multiple sources of S and the reduction of sulfate through both abiotic thermochemical (TSR) and bacterially mediated (BSR) processes. Zn isotopes indicate that the sources of Zn were most likely related to the ELT with various contributions from sediments and basements locally. Pb isotope signatures are suggestive of derivation of Pb from basements and sedimentary rocks with variable influences from the ELIP. Sr isotopes support that mantle-derived rocks, sediments and basements were involved in Pb-Zn mineralization, and they have various contributions in different deposits. We consider that the Pb-Zn deposits in the Upper Yangtze province are the mixed products of multiple S species bearing solutions and metal-rich fluids, both of which were derived from, flowed through or interacted with multiple lithostratigraphic units in the western Yangtze Block. The change of tectonic regimes from extension to compression after eruption of basalts of the ELT, and then to extension during Early Mesozoic, facilitated extraction, migration, and excretion of ore-forming metals and associated fluids. Mixing of fluids and reduction geochemical barrier activated TSR, causing cyclical carbonate dissolution, CO2 degassing and recrystallization (namely carbonate buffer). All these processes triggered continuous precipitation of huge amounts of hydro thermal minerals. Underplating and eruption of ELT basalts provided heat flow, fluids and volatiles, whereas the basalts acted as an impermeable and protective layer, and even as ore-hosting rocks. These Pb-Zn deposits have spatial and genetic association with igneous activities of the ELIP, and are characterized by high ore grades ( > 10 wt% Pb + Zn), high concentrations of associated metals (e.g. Cu, Ag, Ge, and Cd), and medium-low temperatures (usually < 300 degrees C) and salinities (commonly < 20 wt% NaCl equiv.), all of which are significantly different from those of typical Mississippi Valley-type (MVT) deposits. Hence, the carbonate-hosted epigenetic Pb-Zn deposits in the Upper Yangtze metallogenic province representing to a new type of Pb-Zn deposits that are hosted in platform carbonate sequences and formed within compressional zones of passive margin tectonic settings

Pressure-induced coevolution of transport properties and lattice stability in CaK(Fe1-xNix)4As4 (x= 0.04 and 0) superconductors with and without spin-vortex crystal state

Here we report the first investigation on correlation between the transport properties and the corresponding stability of the lattice structure for CaK(Fe1-xNix)4As4 (x=0.04 and 0), a new type of putative topological superconductors, with and without a spin-vortex crystal (SVC) state in a wide pressure range involving superconducting to non-superconducting transition and the half- to full-collapse of tetragonal (h-cT and f-cT) phases, by the complementary measurements of high-pressure resistance, Hall coefficient and synchrotron X-ray diffraction. We identify the three critical pressures, P1 that is the turn-on critical pressure of the h-cT phase transition and it coincides with the critical pressure for the sign change of Hall coefficient from positive to negative, a manifestation of the Fermi surface reconstruction, P2 that is the turn-off pressures of the h-cT phase transition, and P3 that is the critical pressure of the f-cT phase transition. By comparing the high-pressure results measured from the two kinds of samples, we find a distinct left-shift of the P1 for the doped sample, at the pressure of which its SVC state is fully suppressed, however the P2 and the P3 remain the same as that of the undoped one. Our results not only provide a consistent understanding on the results reported before, but also demonstrate the importance of the Fe-As bonding in stabilizing the superconductivity of the iron pnictide superconductors through the pressure window

Reservoir landslide monitoring and mechanism analysis based on UAV photogrammetry and sub-pixel offset tracking: a case study of Wulipo landslide

Introduction: Reservoir landslides undergo large deformations during the early stages of impoundment and maintain long-term persistent deformations during the operational period of the reservoir. The management of reservoir landslides mostly focuses on the early identification, risk assessment during the large deformations, and long-sequence monitoring during long-term persistent deformations, which requires sufficient continuity and integrity of the landslide monitoring data.Methods: Taking the Wulipo (WLP) landslide in Baihetan Reservoir as example, this paper proposes a reservoir landslide monitoring method that integrates field survey, unmanned aerial vehicle (UAV) photogrammetry and global navigation satellite system (GNSS) monitoring, which can effectively eliminate the practical monitoring gaps between multiple monitoring methods and improve the continuity and completeness of monitoring data.Results and discussion: First, this study determined the initiation time of the landslide through the field investigation and collected five period of UAV data to analyze the overall displacement vector of the WLP landslide using sub-pixel offset tracking (SPOT). On the basis of the above data, we compensated for the missing data in GNSS system due to the practical monitoring vacancies by combining the field survey and the landslide-water level relationship. Based on these monitoring data, this paper points out that the WLP landslide is a buoyancy-driven landslide, and whether or not accelerated deformation will occur is related to the maximum reservoir water level. Finally, this study analyzed and discussed the applicability of UAV photogrammetry for reservoir landslide monitoring in the absence of ground control points (GCPs), and concluded that this method can be quickly and flexibly applied to the stage of large deformation of reservoir landslides